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Research Review IgG Testing
date added:01/02/2016

As a practitioner you may not always have the time to look for research which supports
the recommendation of food intolerance tests. Yet knowing which papers to refer to can be helpful. One paper in particular, which is often overlooked, is a study done by Hamilton Dixon MD in 2000.

Despite it’s age it is a very interesting paper as the patients had a variety of different symptoms including diarrhoea, fatigue, migraine as well as less common symptoms like itchy skin, fatigue after meals, ringing in the ears and itchy eyes. In addition to this all patients were refractory patients who had not been able to get an answer using a conventional route.

Dixon (2000) decided to test these patients (114) for food intolerances using an IgG antibody test. Of the 114 patients, 5 had negative results and 16 were lost to follow-up. This left 80 patients who eliminated the foods partially or completely, and so were able to be included in the follow-up of 6-22 months.

The results of the overall study are impressive and elimination of positive foods was successful insignificantly decreasing reported symptoms.

Of those studied who had incapacitating symptoms:
• 25% achieved an 80% or greater improvement level
• 20% achieved a 100% improvement level
• 50% obtained 90% or more relief
• In all 80 patients studied, 71% achieved a 75% or greater improvement level
It’s worth noting that of the patients tested, it included some patients (11) who had tested negative for IgE tests despite a history suggesting the result should have been positive.


Of these patients, all tested positive for IgG antibodies, and 9 showed an 80% symptom
improvement after eliminating their positive foods. Offering an IgG antibody test may therefore have significant value in clinic with clients who have been tested for a classic allergy to no effect. Anecdotally, it is interesting to note that the 15 patients who did not eliminate the foods they tested positive for saw no relief in their symptoms.

References: Dixon HS. (2000). Otolaryngol Head Neck Surg. 2000 Jul;123(1 Pt 1):48-54 


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